Aloe vera
Abstract and key points
- Aloe vera is a cactus-like plant with a long history of medicinal use.
- Aloe vera gel is applied topically and is used for radiation-induced skin problems. However, clinical trials show that it is ineffective for that purpose.
- Aloe vera latex (juice) is taken orally. It has been insufficiently tested as a cancer therapy.
- Oral use might cause abortion in pregnant women.
Aloe vera is a plant remedy used for a wide range of problems. In oncology, it is mostly advocated as a topical treatment to prevent or treat skin irritation after radiotherapy. The trial data, however, seem to indicate that it is ineffective for that purpose. Oral Aloe vera juice has been tested as a cancer treatment but studies are too preliminary to tell whether it is effective. Numerous adverse events are on record but they are generally mild and reversible; oral use might cause abortion.
Citation
Edzard Ernst, CAM-Cancer Consortium. Aloe vera [online document]. http://www.cam-cancer.org/CAM-Summaries/Herbal-products/Aloe-vera. July 26, 2011.Document history
Next update due in autumn 2012.
Summary first published in July 2011, authored by Edzard Ernst.
References
- Ernst E, Pittler MH, Wider B, Boddy K. The Desktop Guide to Complementary and Alternative Medicine. 2nd edition. Edinburgh: Elsevier Mosby. 2006.
- Ulbricht C, Armstrong J, Basch E, Basch S, Dacey C, Dalton S et al. An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. J Herb Pharmacother 2007; 7(3-4):279-323.
- Cárdenas C, Quesada AR, Medina MA. Evaluation of the anti-angiogenic effect of Aloe-emodin. Cell Mol Life Sci 2006; 63(24):3083-3089.
- Xiao B, Guo J, Liu D, Zhang S. Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells. Oral Oncol 2007; 43(9):905-910.
- Esmat AY, Tomasetto C, Rio MC. Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification. Cancer Biol Ther 2006; 5(1):97-103.
- Singh RP, Dhanalakshmi S, Rao AR. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Phytomed 2000; 7(3):209-219.
- Saini M, Goyal PK, Chaudhary G. Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice. J Environ Pathol Toxicol Oncol 2010; 29(2):127-135.
- Chaudhary G, Saini MR, Goyal PK. Chemopreventive potential of Aloe vera against 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice. Integr Cancer Ther 2007; 6(4):405-412.
- El-Shemy HA, Aboul-Soud MA, Nassr-Allah AA, Aboul-Enein KM, Kabash A, Yagi A. Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction. Curr Med CHem 2010; 17(2):129-138.
- Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clin Oncol 2005; 17:478-484.
- Lissoni P, Giana L, Zerbini S, Trabattoni P, Rovelli F. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus Aloe vera in untreatable advanced solid neoplasms. Nat Immun 1998; 16:27-33.
- Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J et al. Phase II double-blind randomized study comparing oral Aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys 2004; 60:171-177.
- Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G et al. A randomized study of chemotharpy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastic cancer. In Vivo 2009; 23:171-176.
- Puataweepong P, Chanachai M, Dangprasert S, Sithatani C, Sawangsilp T, Narkwong L et al. The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study. Asian Biomed 2009; 3(4):375-382.
- Sakai R. Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. Jpn J Cancer Res 1989; 80(6):513-520.
- Worthington HV, Clarkson JE, Eden TOB. Interventions for preventing oral mucositis for patients with cancer receiving treatment (review). Cochrane Database of Syst Rev 2008; 4(DOI: 10.1002/14651858 CD000978 pub3).
- Yokohira M, Matsuda Y, Suzuki S, Hosokawa K, Yamakawa K, Hashimoto N et al. Equivocal colonic carcinogenicity of Aloe arborescens Miller var. natalensis berger at high-dose level in a Wistar Hannover rat 2-y study. J Food Sci 2009; 74(2):T24-30.
- National Toxicology Program. Photocarcinogenesis Study of Aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study). Natl Toxicol Program Tech Rep Ser 2010; Sep(553):1-206.
Legal notice
The present documentation has been compiled by the CAM-CANCER Project with all due care and expert knowledge. However, the CAM-CANCER Project provides no assurance, guarantee or promise with regard to the correctness, accuracy, up-to-date status or completeness of the information it contains. This information is designed for health professionals. Readers are strongly advised to discuss the information with their physician. Accordingly, the CAM-CANCER Project shall not be liable for damage or loss caused because anyone relies on the information.
The present documentation has been compiled by the CAM-CANCER Project with all due care and expert knowledge. However, the CAM-CANCER Project provides no assurance, guarantee or promise with regard to the correctness, accuracy, up-to-date status or completeness of the information it contains. This information is designed for health professionals. Readers are strongly advised to discuss the information with their physician. Accordingly, the CAM-CANCER Project shall not be liable for damage or loss caused because anyone relies on the information.



