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    • Megamin
      • What is Megamin?
      • How well does Megamin work?
      • Is Megamin safe?
      • Megamin conclusions
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Megamin

TMAZ (tribomechanical activated zeolite clinoptilolite) is a special prepared framework quartz mineral. As a result of so-called “tribomechanical activation", these silicates are claimed to have a distinct antioxidant effect. The manufacturer recommends TMAZ as a dietary supplement. TMAZ is sold throughout Europe as the brand Megamin.

Its antioxidant activity is claimed to improve the health of those with malignant diseases (and other conditions). It is suggested that TMAZ supports the normalisation of anaemia, improves general health, decreases pain, improves physical condition and palliates side-effects of chemotherapy like nausea, vomiting, hair and weight loss and improves appetite.

A search for trials confirming these claims was conducted. There is a lack of good quality clinical evidence. The only existing reference is an unpublished best-case-analysis, which was carried out in collaboration with the manufacturer in 2001. This could not confirm the claimed anti-cancer effects. In addition to that, there are no data to confirm the claimed improvements of general health.

Therefore, at present there is no convincing evidence regarding the efficacy of TMAZ supplementation against cancer, regarding the improvement of side effects of cancer therapy by TMAZ or regarding its safety.